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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Five new sesquiterpene lactones from Inula hupehensis
Jie Ren1, Jiang Jiang Qin, Xiang Rong Cheng
1School of Pharmacy, Shanghai Jiao Tong University, Shanghai Dongchuan Rd 800, Shanghai, 200240, China.
Abstract:
Four new pseudoguaianolides (1-4), one new guaianolide (5), together with ten known compounds (6-15) were isolated from the aerial parts of Inula hupehensis. Their structures were elucidated mainly on the basis of 1D and 2D spectroscopic methods and circular dichroism analysis. In addition, compounds 1-10 and 13 were tested for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Compounds 2, 6, 8 and 9 exhibited significant inhibitory activities with IC50 values in the range of 0.6-6.6 μM.
