Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Measuring human mucociliary clearance].

W Stahlhofen1, G Scheuch

  • 1Gesellschaft für Strahlen- und Umweltforschung mbH, Frankfurt am Main.

Pneumologie (Stuttgart, Germany)
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhalation of macrolides: a novel approach to treatment of pulmonary infections.

Advances in experimental medicine and biology·2014
Same author

Inhaler competence in asthma: common errors, barriers to use and recommended solutions.

Respiratory medicine·2012
Same author

Novel devices for individualized controlled inhalation can optimize aerosol therapy in efficacy, patient care and power of clinical trials.

European journal of medical research·2010
Same author

Treatment of systemic diseases by inhalation of biomolecule aerosols.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2010
Same author

Systemic treatment by inhalation of macromolecules--principles, problems, and examples.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2009
Same author

Inhaled insulin--does it become reality?

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2009
Same journal

Pneumologie (Stuttgart, Germany)·2026
Same journal

Aerosol therapy during noninvasive ventilation (NIV) and nasal high-flow therapy (HFT): current technology and consensus-based recommendations.

Pneumologie (Stuttgart, Germany)·2026
Same journal

[Correction: Pharmacotherapy for Tobacco Dependence: Implementation of the Current G-BA Resolution - Erratum: Information from Section E3 of the DGP regarding the G-BA Resolution].

Pneumologie (Stuttgart, Germany)·2026
Same journal

[Pharmacotherapy for Tobacco Dependence: Implementation of the Current G-BA Resolution - Information from Section E3 of the DGP regarding the G-BA Resolution].

Pneumologie (Stuttgart, Germany)·2026
Same journal

[Acute lung failure].

Pneumologie (Stuttgart, Germany)·2026
Same journal

[The internet as a source of information for patients with sarcoidosis].

Pneumologie (Stuttgart, Germany)·2026
See all related articles

A novel inhalation technique allows precise aerosol bolus delivery to specific lung depths. This method revealed slow clearance of particles even from shallow lung regions, impacting drug delivery and respiratory research.

Area of Science:

  • Pulmonary medicine
  • Aerosol science
  • Radiopharmacology

Context:

  • Accurate assessment of particle deposition and clearance in the lungs is crucial for understanding respiratory diseases and optimizing inhaled therapies.
  • Traditional inhalation methods lack precision in controlling aerosol deposition depth.

Purpose:

  • To introduce and evaluate a new inhalation technique for precise aerosol bolus delivery to specific lung depths.
  • To investigate particle clearance kinetics from various lung regions following controlled deposition.

Summary:

  • A new inhalation technique enables controlled injection of aerosol boluses at specific moments during inspiration.
  • Breath-holding at end-inspiration facilitates targeted particle deposition at different lung depths.
  • Radioactive particle clearance was measured over time, revealing slow clearance of a significant fraction even from shallow lung volumes (as low as 35 cm3).

Related Experiment Videos

Impact:

  • Provides a more accurate method for studying lung deposition and clearance patterns.
  • Offers potential for improved targeted drug delivery to specific lung regions.
  • Enhances understanding of aerosol behavior in the respiratory system for both therapeutic and diagnostic applications.