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17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke

Poneh Adib-Samii1, Natalia Rost, Matthew Traylor

  • 1Stroke and Dementia Research Centre, St George’s University of London, London, UK.

Stroke
|May 16, 2013
PubMed
Abstract

Insights

The 17q25 genetic locus is linked to white matter hyperintensities (WMH) in stroke patients. However, this locus is not associated with lacunar stroke, suggesting it does not cause small vessel arteriopathy.

Area of Science:

  • Neurogenetics
  • Neuroimaging
  • Stroke Research

Background:

  • A novel genetic locus at 17q25 was previously linked to white matter hyperintensities (WMH) in individuals without stroke.
  • White matter hyperintensities (WMH) are a common finding on MRI and are associated with various neurological conditions.

Purpose of the Study:

  • To replicate the association between the 17q25 locus and WMH volume (WMHV) in patients diagnosed with ischemic stroke.
  • To investigate if the 17q25 locus is associated with lacunar stroke, which would suggest a role in small vessel arteriopathy.

Main Methods:

  • WMH volume was quantified using MRI in 2588 ischemic stroke cases.
  • Linear regression assessed the association between WMHV and six single-nucleotide polymorphisms (SNPs) at chromosome 17q25.
  • SNPs were also analyzed for association with lacunar stroke in 1854 cases and 51,939 controls, with meta-analyses and genetic risk score approaches employed.

Main Results:

  • The 17q25 locus, particularly SNP rs9894383, showed a significant association with WMHV in ischemic stroke patients (P=0.0006).
  • No significant association was found between the investigated 17q25 SNPs and lacunar stroke.
  • Genetic risk score analysis identified shared genetic factors for WMHV in both community-dwelling individuals and stroke patients.

Conclusions:

  • The study supports the association between the 17q25 locus and white matter hyperintensities.
  • The lack of association with lacunar stroke suggests the 17q25 locus does not promote the small-vessel arteriopathy implicated in lacunar infarction.
Keywords:
Genome-wide Association Studygeneticsleukoaraiosissmall-vessel diseasestroke

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