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Related Concept Videos

Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Cytomegalovirus Disease

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Updated: May 11, 2026

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
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Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

Published on: January 26, 2024

Virus-associated lymphomagenesis.

V Z Tarantul1

  • 1Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.

International Journal of Biomedical Science : IJBS
|May 16, 2013
PubMed
Summary

Viruses cause up to 20% of human cancers, particularly lymphomas. This review examines the causal link between specific viruses and lymphoma development, aiding new cancer treatment strategies.

Keywords:
HIVHIV virus HIVepstein-barr virusepstein-barrvirushepatitis b virushepatitis cvirusherpesviruslymphomaoncogenicityvirus

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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
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Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
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Last Updated: May 11, 2026

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
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Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Viral infections affect billions globally, contributing significantly to human mortality and disease.
  • Viruses are implicated in 15-20% of human cancer incidence, with varying degrees of established causality.
  • Lymphomas are a well-studied cancer group with strong associations with specific viruses.

Purpose of the Study:

  • To review the association between various viruses and human lymphomas.
  • To identify viral genes potentially involved in the neoplastic process of lymphomagenesis.
  • To explore evidence for establishing a causal relationship between viruses and cancer.

Main Methods:

  • Literature review of epidemiological and molecular data.
  • Analysis of oncogenicity in animal models and cell cultures.
  • Case-by-case examination of evidence for viral-cancer causality.

Main Results:

  • Strong associations exist between specific viruses, including Kaposi's sarcoma herpesvirus (KSHV), Epstein-Barr virus (EBV), hepatitis C virus (HCV), human T-cell leukemia virus (HTLV), and human immunodeficiency virus (HIV), and lymphomagenesis.
  • Experimental data in monkeys and antiviral treatment efficacy support a viral role in lymphoma development.
  • Certain viral genes are implicated in the neoplastic transformation leading to lymphomas.

Conclusions:

  • Recognizing viral involvement in lymphomagenesis is crucial for developing novel cancer therapies, diagnostics, and screening methods.
  • Understanding virus-cancer links can reduce the global burden of virus-associated malignancies.
  • Further research into viral oncogenesis can lead to targeted prevention and treatment strategies for lymphomas.