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Related Experiment Video

Updated: May 11, 2026

Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty
09:31

Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty

Published on: February 27, 2018

Saving Implants BMP-2 Application in Revision Total Hip Surgery.

M Jäger1, R Emami, F Thorey

  • 1Department of Orthopedics, Heinrich-Heine University Hospital Dusseldorf (Director: Univ. Prof. Dr. med. R. Krauspe), Moorenstr. 5, D-40225 Dusseldorf, Germany.

International Journal of Biomedical Science : IJBS
|May 16, 2013
PubMed
Summary

This study demonstrates a novel treatment for hip replacement complications. Bone defect healing was achieved using bone morphogenetic protein-2 (BMP-2) and mesenchymal stem cells (MSCs), offering a promising alternative to revision surgery.

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Area of Science:

  • Orthopedic Surgery
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Total hip replacement failure can result from aseptic loosening and osteolysis, with limited non-surgical treatment options for associated bone defects.
  • Adult mesenchymal stem cells (MSCs) and growth factors show potential for bone regeneration and tissue engineering in orthopedic applications.

Observation:

  • A 73-year-old patient presented with pelvic osteolysis following hip arthroplasty, posing a risk for revision surgery.
  • A critical-sized bony defect was treated by filling it with a composite of bone morphogenetic protein-2 (BMP-2) and MSCs.

Findings:

  • The BMP-2/MSC composite successfully promoted progressive bone healing in the critical defect area.
  • The patient experienced complete pain relief and regained full function, with no complications observed 15 months post-treatment.
Keywords:
BMParthroplastybone defectstem cellstotal hip replacement

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The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report
07:45

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

Published on: August 4, 2022

Related Experiment Videos

Last Updated: May 11, 2026

Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty
09:31

Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty

Published on: February 27, 2018

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report
07:45

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

Published on: August 4, 2022

Implications:

  • This case highlights a successful strategy using non-embryonic stem cells and growth factors to treat bone defects in patients with hip endoprostheses.
  • This approach may offer a viable alternative to revision surgery, preserving bone stock and improving patient outcomes.