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Endocrine function in thalassemia intermedia.
H Karamifar1, M Karimi, G H Amirhakimi
1Division of Endocrinology and Metabolism, Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran;
International Journal of Biomedical Science : IJBS
|May 16, 2013
Summary
Thalassemia intermedia (TI) frequently causes growth retardation and growth hormone (GH) deficiency. Early endocrine evaluation in TI patients is crucial for managing complications and enhancing quality of life.
Area of Science:
- Endocrinology
- Hematology
- Genetics
Background:
- Thalassemias are common genetic disorders, with beta-thalassemia causing severe hemolytic anemia.
- Endocrine abnormalities are frequently observed in thalassemia major and intermedia.
Purpose of the Study:
- To investigate endocrine functions in patients with thalassemia intermedia (TI).
- To report the frequency of various endocrine abnormalities in TI patients.
Main Methods:
- Studied 93 patients (11-40 years) with TI.
- Recorded medical history, physical examination, and serum ferritin levels.
- Assessed Growth Hormone (GH), TSH, T4, parathyroid hormone (PTH), and cortisol levels.
Main Results:
- Short stature affected 46% of patients.
- Growth hormone deficiency was found in 31% of patients.
- Primary hypothyroidism occurred in 21.5%, and hypoparathyroidism in 1%.
Conclusions:
- Growth retardation and GH deficiency are common in TI.
- Endocrine evaluation is recommended for TI patients to prevent complications and improve quality of life.
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