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Updated: May 11, 2026
05:57
Peroxisome Staining in Mammalian Cells Using Peroxisome-Specific Probes
Published on: December 19, 2025
Peroxisomes and disease - an overview.
Hannah K Delille1, Nina A Bonekamp, Michael Schrader
1Department of Cell Biology and Cell Pathology, University of Marburg, Robert Koch Str. 6, 35037 Marburg, Germany.
International Journal of Biomedical Science : IJBS
|May 16, 2013
Summary
Peroxisomes are vital cellular organelles involved in metabolism and reactive oxygen species management. This review explores their critical role in inherited disorders, cancer, and conditions like diabetes and inflammation.
Area of Science:
- Cell Biology
- Metabolic Biochemistry
- Human Pathophysiology
Background:
- Peroxisomes are essential subcellular organelles involved in key metabolic processes, including fatty acid oxidation and reactive oxygen species metabolism.
- These organelles are dynamic, with rapid assembly, multiplication, and degradation in response to cellular demands.
- Understanding peroxisome biogenesis and function is crucial for comprehending various inherited disorders and pathophysiological conditions.
Purpose of the Study:
- To provide a comprehensive review of the role of peroxisomes in human diseases.
- To discuss genetic peroxisomal disorders.
- To examine the involvement of peroxisomes in carcinogenesis and oxidative stress-related conditions.
Main Methods:
- Literature review of basic research on peroxisome biogenesis and function.
- Analysis of studies linking peroxisomal dysfunction to inherited diseases.
- Exploration of peroxisomal roles in cancer and oxidative stress-related pathologies.
Main Results:
- Peroxisomal dysfunction underlies several inherited metabolic disorders.
- Peroxisomes play a significant role in the development and progression of cancer.
- Peroxisomal involvement is evident in conditions characterized by oxidative stress, such as inflammation, ischemia-reperfusion injury, and diabetes.
Conclusions:
- Peroxisomes are critical for maintaining human health, and their dysfunction contributes to a spectrum of diseases.
- Further research into peroxisome biology is essential for developing therapeutic strategies for peroxisomal disorders, cancer, and metabolic diseases.
- This review highlights the multifaceted role of peroxisomes in health and disease, emphasizing their importance beyond inherited conditions.
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