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Updated: May 11, 2026

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
09:57

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Published on: August 12, 2019

Role of monocyte chemoattractant protein-1 in myocardial infarction

Hajime Morimoto1, Masafumi Takahashi

  • 1Department of Cardiovascular Medicine and Regeneration, Matsumoto, Japan;

International Journal of Biomedical Science : IJBS
|May 16, 2013
PubMed

Insights

Myocardial infarction (MI) involves inflammation and leukocyte recruitment. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a key chemokine in MI pathophysiology and a potential therapeutic target.

Area of Science:

  • Cardiovascular Biology
  • Immunology
  • Molecular Medicine

Background:

  • Myocardial infarction (MI) triggers inflammatory responses, including leukocyte recruitment, leading to cardiac damage, healing, and scarring.
  • Chemokines, potent chemoattractant cytokines, regulate leukocyte trafficking and inflammatory processes.
  • Chemokines are expressed by non-hematopoietic cells (endothelial cells, smooth muscle cells, cardiomyocytes), with functions beyond leukocyte migration.

Purpose of the Study:

  • To review the critical role of chemokines, particularly monocyte chemoattractant protein-1 (MCP-1/CCL2), in the pathophysiology of myocardial infarction (MI).
  • To discuss the therapeutic potential of targeting MCP-1/CCL2 in the context of MI.

Main Methods:

  • Review of experimental and clinical studies investigating chemokine involvement in MI.
  • Focus on the CC chemokine, monocyte chemoattractant protein-1 (MCP-1/CCL2), and its specific functions in MI.

Main Results:

  • Chemokines play a significant role in the pathophysiology of MI.
  • MCP-1/CCL2 is a frequently investigated chemokine implicated in MI.

Conclusions:

  • MCP-1/CCL2 is integral to the pathological processes following myocardial infarction.
  • Targeting MCP-1/CCL2 presents a promising therapeutic strategy for managing MI.

Keywords:
cytokinesinflammationischemialeukocytemyocardiumreperfusion

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