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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Thrombophilias and pregnancy complications: a case-control study
Larciprete Giovanni1, Angelucci Piero Antonio, Celleno Danilo
1AFaR, Associazione Fatebenefratelli per la Ricerca, Ospedale Fatebenefratelli Isola Tiberina, Rome, Italy; ; Department of Perinatal Medicine, Tor Vergata University, Rome, Italy;
International Journal of Biomedical Science : IJBS
|May 16, 2013
Summary
Inherited thrombophilia, a multi-gene condition, was studied in 301 pregnant women. Antithrombin III deficiency linked to preeclampsia and DIC, while APC resistance associated with abruptio placentae.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Genetics
Background:
- Inherited thrombophilia is often a complex, multi-gene disorder.
- Understanding the link between specific thrombophilic patterns and pregnancy complications is crucial for improved maternal and fetal outcomes.
Purpose of the Study:
- To investigate the association between single inherited thrombophilic gene defects and various pregnancy diseases.
- To identify specific thrombophilic patterns that correlate with adverse pregnancy outcomes.
Main Methods:
- A case-control study involving 301 pregnant women (125 cases, 176 controls).
- Genetic analysis for MTHFR A1298C, MTHFR C677T, Factor V Leiden, PAI-1, and Mutant Prothrombin G20210A using inverse hybridization.
- Assays for plasma homocysteine, Antithrombin III, Protein S levels, and functional activated Protein C resistance.
Main Results:
- MTHFR C677T and hyperhomocysteinemia were the most prevalent thrombophilias.
- Antithrombin III deficiency showed a significant association with preeclampsia and disseminated intravascular coagulopathy (DIC).
- Activated Protein C resistance was linked to abruptio placentae.
Conclusions:
- Antithrombin III deficiency is a significant risk factor for preeclampsia and DIC.
- Activated Protein C resistance is associated with abruptio placentae.
- No association was found between Factor V Leiden or prothrombin gene mutation and preeclampsia in this cohort.
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