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Multiple Sclerosis l: Introduction01:19

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Published on: February 19, 2021

Multiple Sclerosis and HERV-W/MSRV: A Multicentric Study.

Giannina Arru1, Giuseppe Mameli, Vito Astone

  • 1Institute of Clinical Neurology, University of Sassari, Viale San Pietro 10, 07100, Sassari, Italy;

International Journal of Biomedical Science : IJBS
|May 16, 2013
PubMed
Summary

Multiple Sclerosis Retrovirus (MSRV) particles were found in blood and cerebrospinal fluid (CSF) of multiple sclerosis patients. Higher MSRV presence and viral load significantly correlate with MS across diverse European populations.

Keywords:
HERV-WMSRVhuman endogenous retrovirusmultiple sclerosis

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Area of Science:

  • Neuroscience
  • Virology
  • Genetics

Background:

  • Multiple Sclerosis (MS) is a chronic neurological disease with complex etiology.
  • The potential role of infectious agents, such as retroviruses, in MS pathogenesis is under investigation.
  • Multiple Sclerosis Retrovirus (MSRV) has been implicated in MS, but requires further validation in diverse populations.

Purpose of the Study:

  • To investigate the prevalence and viral load of MSRV in a large, multi-centric cohort of MS patients and controls.
  • To analyze MSRV presence in blood and cerebrospinal fluid (CSF) across different European ethnic groups.
  • To determine the association between MSRV and MS in comparison to neurological and healthy controls.

Main Methods:

  • A multicentric study involving 149 MS patients and 153 controls from Sardinia, Spain, Northern Italy, and Sweden.
  • MSRV detection using nested and real-time PCR assays targeting pol and env genes within a single laboratory to minimize variability.
  • Statistical analysis to compare MSRV detection rates and viral loads between MS patients and control groups.

Main Results:

  • Significant differences in MSRV detection were observed between MS patients and both neurological (p<0.05) and healthy controls (p<0.001).
  • The presence and viral load of MSRV were significantly associated with MS across all investigated ethnic groups.
  • MSRV detection rates varied significantly between MS patients and control groups, irrespective of ethnicity.

Conclusions:

  • MSRV presence and viral load are significantly associated with Multiple Sclerosis.
  • The findings support a potential etiological role for MSRV in MS pathogenesis.
  • Further research is warranted to elucidate the mechanisms underlying MSRV's association with MS.