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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Bone densitometric analysis in egyptian hemodialysis patients
Ehab I Mohamed1, Eman S D Khalil
1Department of Medical Biophysics, Medical Research Institute, Alexandria University, Alexandria, Egypt;
International Journal of Biomedical Science : IJBS
|May 16, 2013
Summary
Hemodialysis (HD) patients show lower bone mineral density (BMD) due to elevated phosphate and parathyroid hormone levels. This highlights the need for personalized mineral supplementation in ESRF patients undergoing HD.
Area of Science:
- Nephrology
- Endocrinology
- Bone Metabolism
Background:
- End-stage renal failure (ESRF) necessitates dialysis, often leading to abnormal bone histology.
- Reduced glomerular filtration rate is linked to decreased bone mineral density (BMD).
Purpose of the Study:
- To investigate the impact of hemodialysis (HD) on body composition (BC) and BMD in Egyptian ESRF patients.
- To compare segmental and total BMD between HD patients and healthy controls.
Main Methods:
- Forty ESRF patients undergoing regular HD were matched with 40 healthy controls.
- Body composition (BC) and segmental/total BMD were assessed using dual-energy X-ray absorptiometry.
- Serum levels of calcium, inorganic phosphate, osteocalcin, and parathyroid hormone were monitored.
Main Results:
- HD patients exhibited significantly lower segmental and total BMD compared to controls.
- Elevated serum phosphate, parathyroid hormone (PTH), and osteocalcin (OC) levels were observed in HD patients.
- HD duration positively correlated with reduced BMD in the pelvis, lumbar spine, and total body.
Conclusions:
- Hemodialysis significantly impacts body composition and reduces bone mineral density in ESRF patients.
- Abnormal mineral metabolism (high phosphate, PTH, OC) contributes to decreased BMD.
- Body composition analysis is crucial for tailoring mineral supplementation in HD patients.
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