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Pneumococcal serotypes recovered from health children and their possible association with risk factor in istanbul,

Ferhat Cekmez1, Ferhan Karademir, I Asya Tanju

  • 1Department of Pediatrics, GATA Medical Faculty, Istanbul, Turkey;

International Journal of Biomedical Science : IJBS
|May 16, 2013
PubMed

Insights

Streptococcus pneumoniae colonization in children is 5%, with higher rates in older children and those with specific risk factors. No penicillin resistance was found, indicating vaccine benefits.

Area of Science:

  • Microbiology
  • Pediatrics
  • Epidemiology

Background:

  • * *Streptococcus pneumoniae* is a significant global health concern.
  • * Nasopharyngeal colonization is a key factor in pneumococcal disease development.
  • * Understanding colonization dynamics in children is crucial for public health strategies.

Purpose of the Study:

  • * To determine the nasopharyngeal colonization rate of *S. pneumoniae* in healthy children.
  • * To identify risk factors associated with pneumococcal carriage.
  • * To analyze serogroup distribution and penicillin susceptibility of isolated strains.

Main Methods:

  • * A cross-sectional study involving 500 healthy children.
  • * Nasopharyngeal swabs were collected for bacterial culture.
  • * Statistical analysis was performed to identify risk factors and assess significance.

Main Results:

  • * A 5% carriage rate of *S. pneumoniae* was observed.
  • * Higher colonization rates were found in children aged 7-9 years.
  • * Risk factors included recent upper respiratory tract infection, day-care attendance, and household crowding.
  • * Prevalent serogroups (9, 19, 23, 6, 10, 18) align with those targeted by PCV7.
  • * No penicillin-resistant *S. pneumoniae* strains were detected.

Conclusions:

  • * The study highlights key risk factors for *S. pneumoniae* colonization in children.
  • * The absence of penicillin resistance suggests potential benefits from conjugated vaccines.
  • * Findings support the continued importance of vaccination programs in reducing pneumococcal burden.
Abstract

Keywords:
Streptococcus pneumoniaecolonizationvaccine

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