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[Reasons for postponing anti-tuberculosis BCG vaccination of newborn infants]
Insights
BCG vaccination postponement rates remained stable, but the less reactogenic BCG-M vaccine led to more unjustified delays. Nervous system disorders became a leading reason for postponing tuberculosis vaccination in newborns.
Area of Science:
- Immunology
- Pediatrics
- Public Health
Context:
- Analysis of antituberculous BCG and BCG-M vaccination postponement in Moscow maternity homes.
- Examination of vaccination data from 1985, 1986, and 1988, involving 3100 newborns per group.
- Assessment of reasons for vaccination delays in infants.
Purpose:
- To analyze trends in BCG and BCG-M vaccination postponements.
- To identify the primary reasons for vaccination delays in newborns.
- To evaluate the impact of using a less reactogenic vaccine (BCG-M) on postponement rates.
Summary:
- BCG vaccination postponement rates for medical reasons were consistent across years (5.16%-5.81%).
- Introduction of BCG-M vaccine correlated with a significant increase in unduly indicated postponements (28.1%-44.6%).
- Nervous system disorders emerged as a primary, though often non-contraindicated, reason for postponing vaccination from 1986 onwards.
Impact:
- Highlights potential overuse of vaccination postponements, particularly with less reactogenic vaccines.
- Suggests a need to review and refine vaccination postponement guidelines for newborns.
- Underscores the importance of accurate contraindication assessment in pediatric vaccination programs.
Abstract:
Reasons for antituberculous BCG vaccination postponement in 1985 and those for BCG-M in 1986 and 1988 in 2 maternity homes of Moscow are analysed. All the newborns were divided into 3 groups each 3100 infants strong. A number of the postponed infants in every group for medical reasons appeared to be practically the same, i.e. in 1985-160 (5.16%), in 1986-172 (5.56%) and in 1988-180 (5.81%). After BCG-M vaccine which is less reactogenic, there was an increase in the number of infants with unduly indicated postponed vaccination (in 1985-28.1%, in 1986-44.6% and in 1988-41.7%). At the same time there was a decrease in the number of non-vaccinated infants since they were prematurely born, and as from 1986 the leading vaccination postponement reasons were nervous diseases which are not considered to be counterindications for antituberculous vaccination.