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Published on: April 13, 2010
Heterogeneity of glucocorticoid resistance in patients with bronchial asthma
1Department of Internal Medicine, Akishima Hospital, 1260 Nakagami-cho, Akishima-shi, Tokyo, Japan.
Abstract:
Bronchial asthma is assumed to be the result of excessive inflammation driven by an aberrant T-helper-2 (Th2) response. Recently, it has begun to be recognized that asthma is a heterogeneous disorder. Glucocorticoids (GCs) are effective treatment for bronchial asthma; however, the inflammation in bronchial asthma cannot always be fully controlled. A recent study demonstrated a new underlying mechanism of glucocorticoid resistance that acts in a Th2-independent manner. Thus, responses to GCs are highly heterogeneous.
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