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Photochemical one-pot synthesis of vinblastine and vincristine
1Helsinki University of Technology, Department of Chemistry, Espoo, Finland.
Photochemistry and Photobiology
|May 1, 1990
Abstract:
The naturally occurring cytostatic dimer alkaloids vinblastine 1 and vincristine 2 were photochemically synthesized in slightly acidic aqueous solution from the monomer alkaloids catharanthine 3 and vindoline 4. Multi-centre reactions should obviously be involved and some of the principal photochemistry-associated phenomena here discussed are quite likely to be characteristic even to the biosynthetic reactions yielding vinblastine 1 and vincristine 2 in the cells of Catharanthus roseus.