Related Experiment Video
Updated: May 11, 2026
10:04
Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2 expression
Takuro Igawa1, Yasuharu Sato, Katsuyoshi Takata
1Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
Diagnostic Pathology
|May 17, 2013
Summary
Cyclin D2 is significantly overexpressed in CD5-positive diffuse large B-cell lymphomas (DLBCLs), unlike cyclin D3. This finding highlights cyclin D2 as a potential therapeutic target for this aggressive lymphoma subtype.
Area of Science:
- Oncology
- Hematology
- Molecular Biology
Background:
- D cyclins regulate the cell cycle and are implicated in lymphoma pathogenesis.
- Cyclin D1 is specific to mantle cell lymphoma, but D2 and D3 have less defined roles.
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma with varying subtypes.
Purpose of the Study:
- To investigate the differential expression of cyclin D2 and D3 in de novo CD5-positive and CD5-negative DLBCLs.
- To determine the association of cyclin D2 and D3 expression with DLBCL subtypes.
- To identify potential molecular targets for improving DLBCL treatment outcomes.
Main Methods:
- Analysis of cyclin D2 and D3 expression in a cohort of de novo CD5-positive and CD5-negative DLBCLs.
- Statistical comparison of cyclin expression levels between the two DLBCL groups.
- Utilizing immunohistochemistry or similar techniques to assess protein expression.
Main Results:
- Cyclin D2 was overexpressed in 98% of CD5-positive DLBCLs versus 28% of CD5-negative DLBCLs (p<0.0001).
- No significant difference in cyclin D3 expression was observed between CD5-positive (18/51) and CD5-negative (24/51) DLBCLs (p=0.23).
- Cyclin D2 overexpression is strongly associated with the CD5-positive DLBCL subtype.
Conclusions:
- Cyclin D2 is a key molecular marker closely associated with de novo CD5-positive DLBCL.
- Targeting cyclin D2 may offer a novel therapeutic strategy for this aggressive lymphoma.
- Further research into cyclin D2's role could improve survival rates for DLBCL patients.
Related Concept Videos
02:39Positive Regulator Molecules
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
02:15M-Cdk Drives Transition Into Mitosis
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
02:34Inhibition of Cdk Activity
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
01:22T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...