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Related Experiment Video

Updated: May 11, 2026

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Systemic inflammation, depression and obstructive pulmonary function: a population-based study.

Yanxia Lu¹, Lei Feng, Liang Feng

¹Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, and Department of Psychological Medicine, National University Hospital System, NUHS Tower Block, 9th Floor, 1E Kent Ridge Road, 119228 Singapore, Singapore.

Respiratory Research

|May 17, 2013

Summary

Inflammation markers like Interleukin-6 (IL-6) and C-reactive protein (CRP) are linked to reduced lung function and depressive symptoms in older adults. These cytokines may mediate the connection between lung health and depression.

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Last Updated: May 11, 2026

A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

Area of Science:

Gerontology
Pulmonology
Psychiatry

Background:

Systemic inflammation, indicated by Interleukin-6 (IL-6) and C-reactive protein (CRP), is elevated in chronic conditions like COPD and depression.
Depression frequently co-occurs with COPD, but the role of inflammatory cytokines in linking pulmonary function and depressive symptoms in healthy older adults is underexplored.

Purpose of the Study:

To investigate the association between IL-6, CRP, depressive symptoms, and pulmonary function in older adults without obstructive pulmonary disease.
To determine if proinflammatory cytokines mediate the relationship between pulmonary function and depressive symptoms in this population.

Main Methods:

Analysis of a population-based sample (n=2077) of individuals aged 55+ from the Singapore Longitudinal Ageing Study (SLAS).
Assessment of serum IL-6 and CRP levels, depressive symptoms (GDS-15 ≥5), and pulmonary function (FEV1% predicted, FEV1/FVC% predicted).
Statistical analysis adjusted for smoking status, BMI, and other chronic inflammatory diseases.

Main Results:

Elevated IL-6 and CRP levels were significantly associated with a higher prevalence of depressive symptoms (p<0.05).
High IL-6, high CRP, and depressive symptoms were independently linked to reduced FEV1% predicted and FEV1/FVC% predicted.
A dose-response relationship was observed, with increasing inflammation and/or depressive symptoms correlating with greater pulmonary obstruction.
The association between depressive symptoms and pulmonary obstruction was attenuated by the presence of IL-6 and CRP.

Conclusions:

This study reveals a novel association between depressive symptoms and impaired pulmonary function in older adults, partly mediated by proinflammatory cytokines.
Proinflammatory immune markers and depressive symptoms warrant further investigation as potential indicators for chronic obstructive airway disorders in the elderly.