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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Checkpoint Receptor TIGIT Expressed on Tim-1<sup>+</sup> B Cells Regulates Tissue Inflammation.

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Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples.

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Related Experiment Video

Updated: May 11, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

Transplant rejection and paradigms lost.

Terry B Strom1

  • 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. tstrom@bidmc.harvard.edu

The Journal of Clinical Investigation
|May 17, 2013
PubMed
Summary

This study challenges established ideas about transplant rejection by revealing new signals that guide T cell migration. These findings could lead to better therapies to prevent organ rejection.

Area of Science:

  • Immunology
  • Transplantation Biology
  • Cellular Migration

Background:

  • Transplant rejection involves T cell infiltration of grafted organs.
  • The molecular signals directing T cell migration during rejection are not fully understood.

Purpose of the Study:

  • To investigate the signals governing T cell migration in transplant rejection.
  • To re-evaluate classical paradigms in transplant rejection research.

Main Methods:

  • The study by Walch et al. examined T cell migration dynamics.
  • Experimental approaches were used to identify key signaling pathways.

Main Results:

  • Two widely accepted models of transplant rejection were challenged.

More Related Videos

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Related Experiment Videos

Last Updated: May 11, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

  • New insights into the mechanisms controlling T cell infiltration were uncovered.

    • Conclusions:

    • The findings necessitate a revision of current understanding of transplant rejection.
    • This research has significant implications for developing novel antirejection treatments.