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Updated: May 11, 2026
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Large-cell neuroendocrine carcinoma of prostate. Case report
Luz Maria Moratalla Charcos1, Teresa Pastor Navarro, Virginia Cortes Vizcaino
1Service of Urology, Hospital Universitario Dr. Peset, Valencia, Spain. luzmoratalla@comv.es
Objective:
To report a case of a neuroendocrine differentiation in a prostate cancer patient, a rare subtype.
Methods:
We describe the case of a patient diagnosed with adenocarcinoma of the prostate initially, who presented hematuria due to disease progression with neuroendocrine differentiation despite androgen-deprivation therapy (ADT ).
Discussion:
Prostate cancer is the most common tumor in men. Histologically they are diagnosed as adenocarcinomas, which followed by ADT for a long time, develop neuroendocrine differentiation (NED ).
Conclusions:
The prognostic significance of NED remains controversial. We must think in neuroendocrine differentiation in ADT-treated patient with disease progression and low PSA.