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Updated: May 11, 2026

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Published on: March 17, 2022

Factors associated with diagnosis and operability of chronic thromboembolic pulmonary hypertension. A case-control

Irene M Lang1, Gérald Simonneau, Joanna W Pepke-Zaba

  • 1Irene Lang, Department of Cardiology, Medical University of Vienna, Währinger Gürtel 18 - 20, 1090 Vienna, Austria. irene.lang@meduniwien.ac.at

Thrombosis and Haemostasis
|May 17, 2013
PubMed

Insights

Chronic thromboembolic pulmonary hypertension (CTEPH) and idiopathic pulmonary hypertension (IPAH) share symptoms, but risk factors differ. History of venous thromboembolism suggests CTEPH, while diabetes and higher pulmonary artery pressure suggest IPAH. Operability depends on age, lesion location, and pulmonary vascular resistance.

Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Vascular Medicine

Background:

  • Chronic thromboembolic pulmonary hypertension (CTEPH) and idiopathic pulmonary hypertension (IPAH) present similarly, necessitating differential diagnosis.
  • Identifying operable CTEPH patients is crucial for treatment selection.

Purpose of the Study:

  • Investigate risk factors differentiating CTEPH from IPAH.
  • Determine criteria for selecting operable CTEPH patients.

Main Methods:

  • Case-control study involving 436 CTEPH and 158 IPAH patients across eight European centers (2006-2010).
  • Analyzed risk factors for CTEPH and IPAH, and factors associated with CTEPH operability.

Main Results:

  • CTEPH risk factors: history of acute venous thromboembolism, large pulmonary embolism, non-O blood groups, older age.
  • IPAH risk factors: diabetes mellitus, female gender, higher mean pulmonary artery pressure.
  • Operable CTEPH criteria: younger age, proximal lesions, pulmonary vascular resistance < 1200 dyn.s.cm⁻⁵.
  • Non-operable CTEPH patients showed more overlap in risk factors with IPAH patients than operable CTEPH patients.

Conclusions:

  • Confirmed CTEPH association with venous thromboembolism history and non-O blood groups.
  • Identified diabetes mellitus and higher mean pulmonary artery pressure as indicators for IPAH diagnosis.
  • Non-operable CTEPH shares more risk factor similarities with IPAH than operable CTEPH.

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