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Updated: May 11, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
Published on: February 27, 2026
[Mild bleeding diathesis in a 62-year-old woman with hereditary thrombocytopenia]
R Ventz1, M Hundemer, M Witzens-Harig
1Medizinische Klinik II, Klinikum Worms gGmbH, Gabriel-von-Seidl-Str. 81, 67550, Worms, Deutschland. r.ventz@email.de
Abstract:
A 62-year-old woman presented with severe, isolated thrombocytopenia. Due to the positive family history and normal thrombocyte morphology ANKRD26-associated thrombocytopenia 2 (THC2) was suspected. The diagnosis was confirmed by DNA sequencing. Although this is the first case report on THC2 in Germany, we anticipate that THC2 might be a frequent cause of hereditary thrombocytopenia. A specific therapy was not necessary, but would consist of platelet supplementation.
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