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Miller Fisher's syndrome.

James W Teener¹

¹Department of Neurology, University of Michigan Health System, Ann Arbor, MI 48109-5036, USA. jteener@med.umich.edu

Seminars in Neurology

|May 17, 2013

Summary

This summary is machine-generated.

Miller Fisher's syndrome, a rare Guillain-Barré variant, presents with ataxia, ophthalmoparesis, and areflexia. Anti-GQ1b antibodies are common, indicating a link to other Guillain-Barré forms with similar symptoms.

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FISH for Pre-implantation Genetic Diagnosis

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Published on: February 23, 2011

Area of Science:

Neurology
Immunology
Rare Diseases

Background:

Miller Fisher syndrome (MFS) is a rare neurological disorder.
It is considered a variant of Guillain-Barré syndrome (GBS).
MFS is characterized by a specific triad of symptoms: ataxia, ophthalmoparesis, and areflexia.

Purpose of the Study:

To describe the clinical characteristics of Miller Fisher syndrome.
To investigate the immunological markers associated with MFS.
To understand the relationship between MFS and other GBS variants.

Main Methods:

Review of clinical presentations in MFS patients.
Serological testing for antibodies against GQ1b gangliosides.
Comparison of MFS with other GBS subtypes.

Main Results:

Most MFS patients exhibit measurable antibodies against GQ1b gangliosides in their serum.
The presence of anti-GQ1b antibodies is also observed in GBS patients with significant ataxia or ophthalmoplegia.
Miller Fisher syndrome is typically a self-limiting condition.

Conclusions:

Anti-GQ1b antibodies play a crucial role in the pathogenesis of Miller Fisher syndrome.
The findings suggest an immunological link between MFS and certain GBS variants.
Miller Fisher syndrome generally has an excellent prognosis and is self-limiting.