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Updated: May 11, 2026

Transcutaneous Microcirculatory Imaging in Preterm Neonates
Published on: December 31, 2015
Radiation exposure in extremely low birth weight infants during their neonatal intensive care unit stay
Narayan Prabhu Iyer1, Amy Baumann, Mark Stephen Rzeszotarski
1Department of Pediatrics, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio 44109, USA.
Insights
Extremely low birth weight (ELBW) infants in the neonatal intensive care unit (NICU) receive significant diagnostic X-ray exposure. Monitoring radiation doses is crucial to prevent potential harm to these vulnerable infants.
Area of Science:
- Neonatal care
- Pediatric radiology
- Medical physics
Background:
- Extremely low birth weight (ELBW) infants (<1000 g) may exhibit heightened sensitivity to radiation.
- Neonatal intensive care unit (NICU) stays involve diagnostic imaging procedures for ELBW infants.
Purpose of the Study:
- To estimate the cumulative radiation exposure in surviving ELBW infants during their NICU hospitalization.
- To identify factors associated with radiation exposure in ELBW infants.
Main Methods:
- Retrospective cohort study analyzing medical records of ELBW infants admitted to a NICU.
- Estimation of total entrance skin exposure (ESE) in micro-Gray (μGy) from X-ray procedures.
- Correlation analysis between ESE and gestational age (GA), birth weight (BW), and illness severity (SNAPPE).
Main Results:
- 450 ELBW survivors received a median of 32 X-rays, with a median ESE of 1471 μGy.
- Total ESE was inversely correlated with GA and BW, and positively correlated with illness severity (SNAPPE).
- Gestational age, SNAPPE, and necrotizing enterocolitis were significant predictors of radiation exposure in ELBW infants.
Conclusions:
- ELBW infants undergo substantial diagnostic X-ray exposure during NICU care.
- There is a critical need for vigilant monitoring of X-ray procedures in ELBW infants.
- Minimizing unnecessary radiation exposure is essential for the well-being of ELBW infants.
Background:
Extremely low birth weight (ELBW <1000 g) infants may have increased sensitivity to radiation exposure. Our objective was to estimate the radiation exposure in survivors of ELBW infants during their neonatal intensive care unit (NICU) stay.
Methods:
In this retrospective cohort study, medical records of all ELBW infants who had been admitted to our NICU between May 1999 and October 2009 were reviewed. The infants' total entrance skin exposure [ESE in micro-Gray (μGy)] was estimated.
Results:
Among 450 survivors, the mean gestational age (GA) was 26.3±2.1 weeks, and the mean birth weight (BW) was 774.2±144.4 g. Infants received a median of 32 (range: 1-159) X-rays, with an estimated ESE of 1471 μGy (range: 28-9264). Total ESE was inversely proportional to GA (r=-0.34; P<0.01), and BW (r=-0.39; P=0.01) and proportional to the severity of illness [score for neonatal acute physiology-perinatal extension (SNAPPE), r=0.39; P=0.01]. In a linear regression analysis, GA, SNAPPE and necrotizing enterocolitis were associated with radiation exposure (ESE) in ELBW infants (r2=0.133; P<0.001).
Conclusions:
During their NICU stay, ELBW infants were subjected to a significant number of diagnostic X-ray procedures. Our data highlight the need to closely monitor the number of X-ray procedures ordered to ELBW infants to avoid unnecessary radiation exposure.
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