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Updated: May 11, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
Canine struvite urolithiasis
Douglas Palma1, Cathy Langston, Kelly Gisselman
1Animal Medical Center, New York, New York, USA.
Struvite calculi, or magnesium ammonium phosphate stones, are common in dogs and often linked to infection. Effective management requires addressing stones, infection, and underlying risk factors for prevention.
Area of Science:
- Veterinary Medicine
- Urology
- Microbiology
Background:
- Struvite calculi (magnesium ammonium phosphate) are ancient and prevalent in human and veterinary medicine.
- These stones are the most common uroliths in dogs, frequently associated with urinary tract infections.
- Also known as urease, infection-induced, phosphatic, or triple phosphate stones.
Purpose of the Study:
- To summarize the nature and management of struvite urolithiasis in companion animals.
- To highlight the association between struvite stone formation and infection.
- To emphasize the need for a comprehensive approach to managing this condition.
Main Methods:
- Literature review on struvite calculi composition and etiology.
- Analysis of clinical associations between struvite urolithiasis and infection in dogs.
- Synthesis of current management strategies for struvite urolithiasis.
Main Results:
- Struvite stones are composed of magnesium ammonium phosphate.
- Infection is a primary driver for struvite urolithiasis in most canine cases.
- A multimodal approach is essential for successful management.
Conclusions:
- Struvite urolithiasis requires addressing the stones, concurrent infections, and predisposing factors.
- Understanding the link between infection and stone formation is critical for treatment and prevention.
- Comprehensive management strategies improve outcomes for affected animals.
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