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Functional MRI in conscious rats using a chronically implanted surface coil.

Chris J Martin1, Aneurin J Kennerley, Jason Berwick

  • 1Department of Oncology, University of Oxford, United Kingdom. c.martin@sheffield.ac.uk

Journal of Magnetic Resonance Imaging : JMRI
|May 17, 2013
PubMed
Summary
This summary is machine-generated.

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Researchers developed a new functional MRI (fMRI) method for awake rats, enabling brain activity studies without anesthesia. This technique successfully recorded blood-oxygen-level-dependent (BOLD) responses to stimuli in conscious animals.

Area of Science:

  • Neuroimaging
  • Animal Models
  • Physiology

Background:

  • Anesthesia can alter brain activity and physiological responses.
  • Previous functional MRI (fMRI) studies in rodents often required anesthesia, limiting behavioral relevance.
  • Developing awake fMRI methods is crucial for understanding brain function in naturalistic states.

Purpose of the Study:

  • To establish reliable functional MRI (fMRI) procedures in rats without using anesthetic agents.
  • To enable the study of brain activity in awake, behaving animals using fMRI.
  • To create a foundation for combining behavioral neuroscience with neuroimaging.

Main Methods:

  • Rats were habituated to restraint, scanner noise, and head fixation.
  • A cranial implant with an integrated radiofrequency (RF) coil was used for head stabilization and signal acquisition.
Keywords:
anesthesiafunctional magnetic resonance imagingrat

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  • Blood-oxygen-level-dependent (BOLD) fMRI responses were recorded in awake rats.

    • Main Results:

    • Successful and repeatable BOLD fMRI responses were recorded in awake rats.
    • Whisker stimulation evoked significant BOLD signal changes in the barrel cortex.
    • Hypercapnia induced substantial increases in BOLD signal amplitude.

    Conclusions:

    • The developed methodology allows for unobstructed stimulation of the face and limbs.
    • This technique facilitates a wide range of behavioral and sensory stimulation protocols in fMRI studies.
    • This awake rodent model advances the integration of behavioral neuroscience and functional neuroimaging.