Related Experiment Video
Updated: May 11, 2026
Animal Models of Depression - Chronic Despair Model (CDM)
Published on: September 23, 2021
Planning genomic study in an animal model of depression: a preliminary report
Alireza Farnam1, Ali Fakhari, Leila Roshangar
1Research Team for Psychiatry and Behavioral Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Introduction:
Interaction of several genes is responsible for psychiatric diseases such as depression. Despite the numerous microarray studies in this field, findings are controversial and hard to conclude.
Methods:
Male Wistar rats were randomly selected to receive Chronic Mild Stress model for 4 weeks. Different aspects of depression were measured by forced swimming test, open field trial and sucrose preference tests in the experience group and controls.
Results:
Sucrose was preferred by 40% of CMS group and 80% of controls (p=0.025). Twenty percent of CMS group and 80% of controls were "active" (p=0.001). Last escape was at minute 238 for CMS group and minute 245 for controls and controls had more escape efforts.
Conclusion:
This paper is a preliminary report of a genomic study on animal model of depression which tries to achieve reliable results by a joint of clinical view with recent techniques. Predicted challenges in this procedure and the solutions as well as the limitations may be helpful for future researches.
