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A new bioactive sesquiterpenoid quinone from the Mediterranean Sea marine sponge Dysidea avara
Ashraf Nageeb El-Sayed Hamed1, Wim Wätjen, Roland Schmitz
1Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich-Heine-Universität, Universitätsstrasse 1, Geb. 26.23, 40225 Düsseldorf, Germany.
Abstract:
Investigation of the marine sponge Dysidea avara, family Dysideidae, afforded a new sesquiterpene (-)-N-methylmelemeleone-A (5), in addition to four known sesquiterpenes (+)-avarol (1), (+)-avarone (2), (-)-3'-methylaminoavarone (3) and (-)-4'-methylaminoavarone (4). The structure elucidation of compound 5 was based on 1D and 2D NMR spectroscopic, and HR-MS studies, as well as by comparison with the literature. Cytotoxicity, proteinkinase inhibition, inhibition of NFkB-activity and insecticidal activity were evaluated for the isolated compounds.
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