Correlation between hyperprolactinemia, MRI of hypophysis and clinical presentation in infertile patients

The aim of the study was to investigate symptoms of hyperprolactinemia such as oligomenorrhea, amenorrhea, galactorrhea, and correlation between hyperprolactinemia and MRI of hypophysis in infertile women.

During the 10 years period, we have studied 87 patients investigated for infertility causes and with hyperprolactinemia findings, in our patients we have controled the serum prolactin levels, performed MRI of hypophysis, evaluated menstrual cycle disturbances and galactorrhea. Patients were between 20-43 of age.

MRI of hypophysis confirmed prolactinoma (microadenoma) in 75.86% of our patients, while 24.14% had a normal MRI. Galactorrhea was demonstrated in 56.32% of patients. Oligomenorrhoea occured in 25.29%, and secondary amenorrhea in 14.94% of patients with hyperprolactinemia and infertility. The results show statistically significant difference in the average findings of serum prolactin levels on the day 8 and 21 of menstrual cycle in patients with or without microadenoma.

Menstrual cycle disturbancies (oligomenorrhea and secondary amenorrhea) in patients with hyperprolactinemia and infertility occured in 40.33% of patients. We have noted statisctically significant correlation between the serum prolactin levels on the day 8 of menstrual cycle and the microadenoma size, which was not found on the 21 day of menstrual cycle.