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Statistical considerations for the development of prescriptive fetal and newborn growth standards in the

D G Altman1, E O Ohuma,

  • 1Centre for Statistics in Medicine, Wolfson College Annexe, University of Oxford, Oxford, UK.

BJOG : an International Journal of Obstetrics and Gynaecology
|May 18, 2013
PubMed

Insights

The INTERGROWTH-21st Project is developing growth standards for babies. This involves statistical planning for fetal, newborn, and preterm infant studies to ensure accurate growth metrics.

Area of Science:

  • Maternal and Child Health
  • Biostatistics
  • Pediatric Growth Standards

Background:

  • Global variations in fetal and newborn growth necessitate standardized assessment tools.
  • Existing growth charts may not accurately reflect diverse populations.
  • The INTERGROWTH-21st Project aims to address these limitations.

Purpose of the Study:

  • To develop prescriptive, evidence-based standards for fetal, neonatal, and preterm infant growth.
  • To establish internationally recognized growth references.
  • To provide tools for monitoring and evaluating child growth globally.

Main Methods:

  • The project integrates three studies: Fetal Growth Longitudinal Study (FGLS), Preterm Postnatal Follow-up Study (PPFS), and Newborn Cross-Sectional Study (NCSS).
  • Statistical methodologies are being developed to guide the construction of growth standards.
  • Sample size calculations and main analysis principles are key statistical considerations.

Main Results:

  • Statistical frameworks are established for the FGLS, PPFS, and NCSS.
  • Sample size requirements are determined to ensure robust standard development.
  • Principles for main statistical analyses are outlined for each study component.

Conclusions:

  • The INTERGROWTH-21st Project's statistical approach is foundational for creating reliable growth standards.
  • Rigorous statistical planning ensures the validity and applicability of the developed growth references.
  • These standards will aid in identifying and managing growth deviations in infants worldwide.

Keywords:
Sample sizefetal growthlongitudinal studyprescriptive standards, INTERGROWTH-21ststatistical aspects

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