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Updated: May 11, 2026

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
Published on: April 21, 2014
About the specialized myocardial conducting tissue
Alfredo de Micheli Serra1, Pedro Iturralde Torres2, Alberto Aranda Fraustro3
1Research Fallow, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan, DF, Mexico.
Discoveries tracing the heart's electrical conduction system, from the sinus atrial node to the atrioventricular node and ventricular pathways, are detailed. Key structures like internodal bundles and their roles in cardiac function are explained.
Area of Science:
- Cardiology
- Cardiac Electrophysiology
- Medical History
Background:
- The atrioventricular conducting system is crucial for coordinated heart contractions.
- Understanding its historical discovery provides context for current cardiac research.
Purpose of the Study:
- To chronologically outline the key discoveries regarding the location and structure of the atrioventricular conducting system.
- To detail the components of the cardiac conduction system, including nodes, bundles, and pathways.
Main Methods:
- Historical review of scientific literature and landmark discoveries.
- Descriptive analysis of the anatomical structures of the cardiac conduction system.
Main Results:
- The sinus atrial node was identified in 1907 by Keith and Flack.
- The atrioventricular node (AV node) was discovered by Tawara and Aschoff in 1906.
- Key internodal pathways (Bachmann's, Wenckebach's, Thörel's bundles) and ventricular conduction systems are described, including the potential existence of a left middle subdivision.
Conclusions:
- The study provides a comprehensive historical overview of the atrioventricular conducting system's discovery.
- It clarifies the anatomical details of the cardiac conduction system, essential for understanding heart function and disease.
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