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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Related Experiment Video

Updated: May 11, 2026

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Na&#239;ve-like State with Improved Multilineage Differentiation Potency
09:07

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

Published on: June 10, 2018

Standardization of human stem cell pluripotency using bioinformatics.

Michael W Nestor, Scott A Noggle

    Stem Cell Research & Therapy
    |May 18, 2013
    PubMed
    Summary

    Standardizing human stem cell pluripotency assays is crucial for regenerative medicine. This review explores bioinformatics and gene expression profiling to ensure high-quality stem cells for research and therapeutic applications.

    Area of Science:

    • Stem cell biology
    • Regenerative medicine
    • Developmental biology

    Background:

    • Human stem cells are vital for studying development and disease.
    • Their differentiation potential offers avenues for regenerative medicine.
    • Standardizing pluripotency assays remains a key challenge.

    Purpose of the Study:

    • To review technologies for standardized, high-quality human stem cell production.
    • To focus on pluripotency assays using bioinformatics and gene expression profiling.
    • To improve prediction of stem cell utility for regenerative medicine.

    Main Methods:

    • Bioinformatics analysis of stem cell data.
    • Gene expression profiling for pluripotency assessment.
    • Review of current high-throughput stem cell derivation and screening technologies.

    More Related Videos

    A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation
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    A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation

    Published on: October 4, 2024

    Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
    09:34

    Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

    Published on: November 27, 2017

    Related Experiment Videos

    Last Updated: May 11, 2026

    Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Na&#239;ve-like State with Improved Multilineage Differentiation Potency
    09:07

    Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

    Published on: June 10, 2018

    A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation
    11:38

    A Live-cell Image-Based Machine Learning Strategy to Monitor Pluripotent Stem Cell Differentiation

    Published on: October 4, 2024

    Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
    09:34

    Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

    Published on: November 27, 2017

    Main Results:

    • Current technologies aim to standardize stem cell quality.
    • Bioinformatics and gene expression profiling offer robust assay methods.
    • Improved prediction of stem cell utility is achievable.

    Conclusions:

    • Standardization of human stem cell assays is essential for progress.
    • Bioinformatics and gene expression profiling are key tools.
    • These advancements will accelerate regenerative medicine applications.