Locally advanced prostate cancer: current controversies and optimisation opportunities

Area of Science:

• Oncology
• Urology

Background:

• Prostate cancer is the most common male malignancy globally.
• Incidence of locally advanced prostate cancer has decreased due to PSA screening.
• Management of locally advanced prostate cancer is controversial.

Purpose of the Study:

• To review current management strategies for locally advanced prostate cancer.
• To identify unresolved issues and future research directions.
• To explore the role of biomarkers in personalized medicine for prostate cancer.

Main Methods:

• Literature review of current treatment approaches.
• Analysis of unresolved clinical questions.
• Discussion of emerging therapeutic strategies and biomarkers.

Main Results:

• Standard care involves combined radiation and androgen deprivation therapy.
• Unresolved issues include dose-escalated radiation, surgical benefits, and systemic therapy roles.
• Biomarker research is crucial for personalized risk assessment.

Conclusions:

• Optimal management of locally advanced prostate cancer requires further investigation.
• Personalized medicine approaches incorporating biomarkers are essential.
• Future research should address dose escalation, surgical utility, and novel systemic therapies.