Related Experiment Video
Updated: May 11, 2026
08:53
Integrating Computerized Linguistic and Social Network Analyses to Capture Addiction Recovery Capital in an Online Community
Published on: May 31, 2019
Connecting with an old partner in a new way
John E Burke1, Roger L Williams
1MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Cancer Cell
|May 18, 2013
Summary
Researchers found a new way insulin receptor substrate 1 interacts with a cancer-driving protein. A new peptide drug targeting this interaction slowed tumor growth in mice, offering a potential new cancer therapy.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- The phosphoinositide 3-kinase (PI3K) pathway is frequently dysregulated in cancer.
- Oncogenic variants of the p110α catalytic subunit of PI3K are key drivers of tumor growth.
- Understanding novel regulatory mechanisms of PI3K is crucial for developing targeted therapies.
Purpose of the Study:
- To investigate a non-canonical interaction between insulin receptor substrate 1 (IRS1) and oncogenic PI3K variants.
- To explore the therapeutic potential of disrupting this IRS1-PI3K interaction.
Main Methods:
- Utilized biochemical assays to characterize the interaction between IRS1 and PI3K variants.
- Developed and tested a cell-penetrant peptide designed to inhibit this interaction.
- Assessed the effect of the peptide on PI3K signaling and tumor growth in preclinical mouse models.
Main Results:
- Identified a novel, non-canonical interaction between IRS1 and specific oncogenic PI3K p110α variants.
- Demonstrated that a cell-penetrant peptide effectively disrupts this interaction.
- Showed that peptide-mediated disruption of the IRS1-PI3K interaction leads to downregulation of PI3K signaling.
- Observed significant inhibition of tumor growth in mice treated with the disruptive peptide.
Conclusions:
- The interaction between IRS1 and oncogenic PI3K p110α represents a new therapeutic vulnerability.
- Targeting this interaction with a cell-penetrant peptide offers a promising strategy for cancer treatment.
- Further development of peptide-based inhibitors could lead to novel oncological therapies.
Related Concept Videos
02:12Relationship Formation
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
01:27Relationship Growth
Interpersonal relationships progress through stages, beginning with awareness and moving toward mutuality, where emotional connections deepen. While many relationships remain at moderate levels of mutuality, deeper connections form through self-disclosure, trust, and interdependence.Self-DisclosureSelf-disclosure involves revealing personal information, starting with surface-level details and gradually progressing to more intimate content. As trust grows, individuals feel more comfortable...
01:29Relationship with Other Adult Family Members and Siblings
Other adult family members and siblings play a crucial role in shaping children’s social and emotional development. While parents or primary caregivers are often the central figures in early attachment and socialization, other adults in a child’s life, such as grandparents, aunts, and uncles, can significantly influence developmental outcomes. These influences depend on each adult’s personality and may help compensate when a primary caregiver is emotionally distant or inconsistent. For...
01:27Companionate Love
Companionate love is a fundamental aspect of long-term relationships, characterized by deep affection, mutual respect, and emotional intimacy. Unlike passionate love, which is driven by intense emotions and physical attraction but often declines over time, companionate love remains stable and can even strengthen with shared experiences and commitment. Psychological and biological mechanisms underpin this enduring form of love, influencing relationship longevity and satisfaction.Stability and...
01:28Ending Relationships
The dissolution of intimate relationships presents complex emotional and psychological challenges, particularly when emotional bonds are strong, the relationship is long-standing, and perceived alternatives are limited. This distress often intensifies in romantic breakups, where the initiator may experience greater turmoil than the rejected partner. Contributing factors include residual attachment, guilt over causing pain, and uncertainty about how to manage the situation. The stress is further...
01:26Couples Therapy
Couples therapy is a therapeutic approach designed to help individuals in intimate relationships address conflicts, improve communication, and foster healthier dynamics. It is appropriate for couples at various stages, including those who are dating, married, or in long-term partnerships, and aims to support partners in navigating their unique relational challenges.
Core Principles and Techniques
Couples therapy often incorporates cognitive-behavioral principles to identify and modify negative...
Core Principles and Techniques
Couples therapy often incorporates cognitive-behavioral principles to identify and modify negative...