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Personalized medicine in psychiatry: problems and promises
Uzoezi Ozomaro1, Claes Wahlestedt, Charles B Nemeroff
1University of Miami, Leonard M, Miller School of Medicine, Miami, FL, USA.
BMC Medicine
|May 18, 2013
Summary
Personalized medicine tailors treatments to individual physiology for better disease prediction, diagnosis, and treatment. This review explores its application in major depressive disorder, bipolar disorder, and schizophrenia, focusing on biomarkers and neuroimaging.
Area of Science:
- Psychiatry
- Genomics
- Neuroscience
Background:
- Personalized medicine leverages individual physiological characteristics for disease risk prediction and treatment response.
- Optimizing diagnosis and treatment is crucial for reducing morbidity and mortality in psychiatric disorders.
Purpose of the Study:
- To review foundational studies for personalized medicine in major depressive disorder, bipolar disorder, and schizophrenia.
- To highlight emerging applications, including novel biomarkers and neuroimaging, for advancing psychiatric personalized medicine.
Main Methods:
- Review of selected studies on personalized medicine in major psychiatric disorders.
- Identification and discussion of emerging biomarkers and neuroimaging techniques.
Main Results:
- Foundational research is establishing the basis for personalized approaches in major depressive disorder, bipolar disorder, and schizophrenia.
- Novel biomarkers and advanced neuroimaging show promise for future psychiatric personalized medicine.
Conclusions:
- Personalized medicine holds significant potential to improve outcomes in psychiatry by tailoring interventions to individual patient profiles.
- Continued research into biomarkers and neuroimaging is essential for realizing the full benefits of personalized psychiatry.
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