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Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Transient Ischemic Attack l: Introduction

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

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Updated: May 11, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Early mobilization after acute stroke.

Antje Sundseth¹, Bente Thommessen², Ole Morten Rønning¹

¹Department of Neurology, Medical Division, Akershus University Hospital, Lørenskog, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association

|May 18, 2013

Summary

This summary is machine-generated.

Early mobilization after stroke is crucial for recovery. This study found that neither mobilizing patients within 24 hours nor between 24 to 48 hours significantly impacted good outcomes 3 months poststroke.

Keywords:

Clinical trial early mobilization outcome outcome predictive factors predictors stroke

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Last Updated: May 11, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Area of Science:

Neurology
Rehabilitation Medicine
Clinical Trials

Background:

Stroke unit care improves patient outcomes compared to general medical wards.
Early mobilization is a key component of stroke unit care, but its impact on diverse patient groups requires further investigation.
Uncertainty exists regarding the optimal timing of mobilization for acute stroke patients.

Purpose of the Study:

To compare the proportion of patients achieving a modified Rankin Scale score of ≤2 at 3 months poststroke.
To assess outcomes in patients mobilized within 24 hours versus those mobilized between 24 to 48 hours after admission.
To identify other factors associated with a good functional outcome after acute stroke.

Main Methods:

A prospective, randomized, controlled trial with blinded outcome assessment was conducted.
Patients were assigned to early mobilization (within 24 hours) or delayed mobilization (24-48 hours) groups.
Binary logistic regression analyzed predictors of good outcome, including mobilization timing, age, sex, stroke risk factors, and NIH Stroke Scale score.

Main Results:

Fifty-five percent of all patients achieved a good outcome (modified Rankin Scale score ≤2) at 3 months.
Median mobilization times were 7.5 hours for the early group and 30.0 hours for the delayed group.
No significant association was found between mobilization timing and good outcome.

Conclusions:

The timing of initial mobilization (within 24 hours vs. 24-48 hours) was not associated with functional outcome at 3 months poststroke.
None of the investigated candidate variables, including mobilization timing, age, sex, stroke risk factors, or admission NIH Stroke Scale score, predicted good outcome.