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Cognitive changes in patients with multiple cerebral infarcts.

V L Babikian1, N Wolfe, R Linn

  • 1Department of Neurology, Boston University School of Medicine, Massachusetts.

Stroke
|July 1, 1990
PubMed
Summary

Multiple cerebral infarcts significantly impair cognitive function across most domains. While nearly all affected patients show some cognitive deficits, only a minority meet dementia criteria using the Mini-Mental State Examination.

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Area of Science:

  • Neurology
  • Neuropsychology
  • Cerebrovascular Disease

Background:

  • The impact of multiple cerebral infarcts on neurobehavioral status lacks consensus.
  • Cerebral infarcts, particularly multiple occurrences, can affect cognitive functions.

Purpose of the Study:

  • To evaluate cognitive function in patients with multiple cerebral infarcts.
  • To compare cognitive performance between mixed and lacunar infarct types and controls.

Main Methods:

  • Administered a comprehensive neuropsychological test battery to 23 male patients with multiple cerebral infarcts.
  • Classified patients into mixed (n=12) or lacunar (n=11) infarct groups based on CT scans.
  • Compared patient groups with 11 age-, sex-, and education-matched controls.

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Main Results:

  • The mixed infarct group scored significantly lower than controls across all cognitive domains.
  • The lacunar infarct group showed cognitive impairment in most domains, except attention.
  • 30% of patients had Mini-Mental State Examination scores indicative of dementia ( < 24).

Conclusions:

  • Virtually all patients with multiple cerebral infarcts experience some cognitive impairment.
  • The Mini-Mental State Examination may underestimate dementia prevalence in patients with multiple cerebral infarcts.