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Bioanalytical separation and preconcentration using ionic liquids.

Leticia B Escudero¹, Alexander Castro Grijalba, Estefanía M Martinis

¹Laboratory of Analytical Chemistry for Research and Development (QUIANID), Instituto de Ciencias Básicas, Universidad Nacional de Cuyo, Padre J. Contreras 1300, Parque Gral. San Martín, M5502JMA, Mendoza, Argentina.

Analytical and Bioanalytical Chemistry

|May 18, 2013

Summary

Ionic liquids offer eco-friendly alternatives for separating and concentrating analytes in biological samples. These novel solvents show promise for various analytical applications, improving detection limits and environmental compatibility.

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Area of Science:

Analytical Chemistry
Green Chemistry
Biotechnology

Background:

Ionic liquids (ILs) are recognized for their unique properties, including low vapor pressure and high thermal stability.
Their favorable characteristics make them suitable replacements for volatile organic compounds in analytical procedures.
ILs present an opportunity to develop more sustainable and efficient analytical methods.

Purpose of the Study:

To critically review the application of ionic liquids in the separation and preconcentration of bioanalytes.
To highlight the use of ILs for determining organic and inorganic analytes in diverse biological matrices.
To assess the advantages and challenges associated with IL-based analytical techniques.

Main Methods:

Review of recent literature on ionic liquid applications in bioanalysis.
Focus on microextraction techniques like dispersive liquid-liquid microextraction (DLLME) and single-drop microextraction (SDME).
Comparison of IL-based methods regarding detection limits and environmental impact.

Main Results:

Ionic liquids have been successfully employed for the separation and preconcentration of a wide range of analytes.
IL-based methods demonstrate effectiveness in analyzing contaminants and biomolecules in samples like urine, blood, and hair.
DLLME and SDME techniques utilizing ILs show significant potential for sensitive and selective bioanalysis.

Conclusions:

Ionic liquids are promising for developing greener and more efficient analytical methods for bioanalysis.
Further research is needed to address challenges and optimize IL-based separation and preconcentration techniques.
ILs offer a viable path towards reducing the environmental footprint of analytical chemistry.