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Related Concept Videos

Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
Probiotics01:22

Probiotics

Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...

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Updated: May 11, 2026

Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics
09:09

Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics

Published on: October 13, 2020

The comprehensive peptaibiotics database.

Norbert Stoppacher1, Nora K N Neumann, Lukas Burgstaller

  • 1Center for Analytical Chemistry, Department of Agrobiotechnology, University of Natural Resources and Life Sciences, Vienna, BOKU, Konrad Lorenz Straße 20, A-2430 Tulln.

Chemistry & Biodiversity
|May 18, 2013
PubMed
Summary
This summary is machine-generated.

A new database catalogs 1043 peptaibiotics, which are antibiotic peptides containing α-aminoisobutyric acid (Aib). This comprehensive resource aids researchers in exploring these fungal-derived compounds.

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Semi-Quantitative Analysis of Peptidoglycan by Liquid Chromatography Mass Spectrometry and Bioinformatics
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

  • Biochemistry
  • Mycology
  • Bioinformatics

Background:

  • Peptaibiotics are a class of peptides characterized by the presence of α-aminoisobutyric acid (Aib) and antibiotic activity.
  • These compounds are primarily produced by hypocrealean fungi and have been studied since 1958.
  • The existing 'Peptaibol Database' (established 1997) served as a foundation for further compilation.

Purpose of the Study:

  • To create a comprehensive database of known peptaibiotics.
  • To consolidate and present detailed information on peptaibiotic properties.
  • To provide a freely accessible software tool for peptaibiotic research.

Main Methods:

  • An exhaustive literature survey was conducted to identify known peptaibiotics.
  • Data from the literature and the 'Peptaibol Database' were compiled.
  • A software tool was developed using Microsoft Access to organize and query the information.

Main Results:

  • A list of 1043 peptaibiotics was compiled.
  • The Comprehensive Peptaibiotics Database was created, containing data up to December 14, 2012.
  • The database includes details on peptide category, amino acid sequence, producing fungus, molecular formula, and mass.

Conclusions:

  • The Comprehensive Peptaibiotics Database is a versatile, freely available resource for researchers.
  • It facilitates automated searches and retrieval of valuable information on peptaibiotics.
  • This database enhances the study of fungal-derived antibiotic peptides.