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08:46

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Neonatal meningitis and sepsis by Chryseobacterium indologenes: a rare and resistant bacterium

Vandana Kalwaje Eshwara1, Arun Sasi, Frenil Munim

  • 1Department of Microbiology, Kasturba Medical College, Manipal University, Manipal, Udupi, Karnataka, 576104, India, vandanake@gmail.com.

Indian Journal of Pediatrics
|May 18, 2013
PubMed

Insights

Early neonatal meningitis caused by rare bacteria is uncommon. Ciprofloxacin effectively treated a case of Chryseobacterium indologenes meningitis and sepsis, despite the pathogen

Area of Science:

  • Neonatal infectious diseases
  • Clinical microbiology
  • Antimicrobial resistance

Background:

  • Early neonatal meningitis is rare, often linked to environmental sources.
  • Non-fermenting Gram-negative bacilli (NFGNB) are infrequent causes of neonatal meningitis.
  • Chryseobacterium indologenes is a rare NFGNB with unusual antimicrobial resistance patterns.

Observation:

  • A case of neonatal meningitis and sepsis caused by Chryseobacterium indologenes is presented.
  • The bacterium exhibited resistance to beta-lactams, carbapenems, and aminoglycosides.
  • The clinical presentation and microbiological findings are detailed.

Findings:

  • Successful treatment of Chryseobacterium indologenes meningitis and sepsis was achieved with ciprofloxacin.
  • This outcome is notable given the bacterium's resistance to multiple standard antibiotic classes.
  • Ciprofloxacin demonstrated efficacy against this rare pathogen in a neonatal setting.

Implications:

  • Highlights the potential for ciprofloxacin in treating infections caused by multidrug-resistant NFGNB.
  • Suggests the need for broader antimicrobial susceptibility testing and consideration of alternative agents.
  • Informs clinical management strategies for rare bacterial meningitis in neonates.

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