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Does an NSAID a day keep satellite cells at bay?

Abigail L Mackey1

  • 1Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, and Centre for Healthy Ageing, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|May 18, 2013
PubMed
Summary

Nonsteroidal anti-inflammatory drugs (NSAIDs) may hinder muscle repair in young athletes by affecting satellite cells. Elderly individuals might experience benefits, but further research is needed.

Keywords:
NSAIDsexercisegrowth factormuscle adaptationsatellite cells

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Area of Science:

  • Exercise physiology
  • Muscle biology
  • Pharmacology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used by athletes.
  • Evidence suggests NSAIDs may negatively impact skeletal muscle adaptation to exercise in young individuals.
  • Satellite cells are crucial for muscle repair and maintenance.

Purpose of the Study:

  • To review the impact of NSAIDs on satellite cell activity.
  • To examine signaling pathways potentially altered by NSAIDs.
  • To address discrepancies in NSAID effects between young and elderly individuals.

Main Methods:

  • Literature review focusing on NSAID effects on muscle adaptation.
  • Analysis of NSAID influence on satellite cell function and related signaling pathways.
  • Consideration of age-related differences in NSAID response.

Main Results:

  • NSAIDs may inhibit satellite cell activity in young individuals, potentially impairing muscle repair.
  • Growth factors, inflammatory cells, and connective tissue are key mediators in NSAID-affected muscle.
  • Elderly individuals might benefit from NSAIDs, though this requires more investigation.

Conclusions:

  • NSAIDs' long-term effects on muscle adaptation, especially with chronic use in athletes, are unclear.
  • Further research is warranted to elucidate NSAID mechanisms on satellite cells and prostaglandin signaling.
  • Age appears to be a significant factor in NSAID efficacy and safety for muscle health.