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Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
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Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
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Drugs for Treatment of Diarrhea-Predominant IBS

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
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Antibiotic Selection00:57

Antibiotic Selection

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Related Experiment Video

Updated: May 11, 2026

Evaluation of Antioxidant and Anthelmintic Properties of Tithonia diversifolia Extracts Against Gastrointestinal Nematode Eggs Using In Vitro Assays
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Evaluation of Antioxidant and Anthelmintic Properties of Tithonia diversifolia Extracts Against Gastrointestinal Nematode Eggs Using In Vitro Assays

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Anthelmintics Resistance; How to Overcome it?

Hatem A Shalaby1

  • 1Department of Parasitology and Animal Diseases, National Research Center, Giza, Egypt.

Iranian Journal of Parasitology
|May 18, 2013
PubMed
Summary

Anthelmintic resistance in livestock parasites is a growing global problem. Strategies like refugia, targeted treatments, and integrated approaches are crucial to slow resistance and ensure animal health.

Area of Science:

  • Veterinary Parasitology
  • Animal Health
  • Drug Resistance

Background:

  • Anthelmintic resistance in parasitic helminthes is a significant global challenge in livestock production.
  • Resistance threatens the future welfare and productivity of grazing animals.
  • Gastrointestinal nematodes exhibit resistance to all major anthelmintic drug classes.

Purpose of the Study:

  • To review the factors contributing to anthelmintic resistance in livestock parasites.
  • To explore strategies for controlling and delaying the development of anthelmintic resistance.
  • To propose sustainable parasite control methods beyond sole reliance on anthelmintics.

Main Methods:

  • Literature review of factors contributing to anthelmintic resistance.
  • Analysis of current and proposed strategies for resistance management.
Keywords:
AnthelminticControlHelminthsResistance

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  • Synthesis of integrated parasite control approaches.

    • Main Results:

    • Frequent use of single anthelmintics, sub-optimal doses, and mass treatments accelerate resistance.
    • Maintaining parasites in refugia preserves susceptible genes, delaying resistance.
    • Integrated strategies including resistant breeds, pasture management, and vaccines are effective.

    Conclusions:

    • Anthelmintic resistance requires a shift from sole drug use to integrated, sustainable parasite control.
    • Targeted selective treatments and combination drug strategies are vital.
    • New anthelmintics should be used judiciously, potentially in combination with older drugs.