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Noyori hydrogenation: aromaticity, synchronicity, and activation strain analysis

Olalla Nieto Faza1, Carlos Silva López, Israel Fernández

  • 1Departmento de Química Orgánica, Universidade de Vigo, Lagoas-Marcosende s/n 36310, Vigo, Spain.

The Journal of Organic Chemistry
|May 21, 2013
PubMed
Summary

Computational studies reveal Noyori hydrogenation and double group transfer reactions share a concerted mechanism. Differences in synchronicity and aromaticity were observed, with heteroatoms lowering reaction barriers by increasing interaction energy.

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