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Related Concept Videos

Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...

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Related Experiment Video

Updated: May 11, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

[Online hemodiafiltration: is it really more expensive?].

Ludivine Lebourg1, Sonia Amato, Daniel Toledano

  • 1Centre d'hémodialyse Henri-Küntziger, AURA, 5, rue du Bessin, 75015 Paris, France.

Nephrologie & Therapeutique
|May 21, 2013
PubMed
Summary

Online hemodiafiltration (OL-HDF) offers significant patient benefits but incurs costs. This study found the real overcost of OL-HDF compared to high flux hemodialysis (HF-HD) ranges from -1.29 to +4.58 euros per session.

Related Experiment Videos

Last Updated: May 11, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Area of Science:

  • Nephrology
  • Health Economics

Context:

  • Online hemodiafiltration (OL-HDF) is recognized for improving patient outcomes and enhancing the removal of middle-weight molecules.
  • The perceived additional cost of OL-HDF may hinder its widespread adoption in dialysis centers.
  • High flux hemodialysis (HF-HD) serves as the comparator for cost analysis.

Purpose:

  • To conduct a precise pharmaco-economic evaluation to determine the actual overcost of OL-HDF versus HF-HD with standard priming.
  • To identify and quantify additional costs associated with consumables, monitors, water usage, and microbiological analyses for OL-HDF.

Summary:

  • The study analyzed costs in a center performing over 28,000 sessions annually, with 70% utilizing OL-HDF (90% post-dilution).
  • Consumable overcosts varied from -2.55 to +3.35 euros per session, microbiological analysis added +1.1 euros, and water consumption increased costs by +0.15 to +0.23 euros per session.
  • The total cost difference for OL-HDF was found to range from -1.29 to +4.58 euros per session, contingent on the specific monitor and OL-HDF modality employed.

Impact:

  • Provides accurate pharmaco-economic data to inform decisions regarding OL-HDF implementation.
  • Highlights that the cost-effectiveness of OL-HDF is variable and depends on operational factors.
  • Aims to facilitate the broader adoption of OL-HDF by clarifying its real economic impact.