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Updated: May 11, 2026
10:56
A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
Published on: September 15, 2018
Dysfunctional co-expression network analysis of familial hypercholesterolemia.
Yizhou Ye1, Kefei Li, Jian Liu
1Department of Cardiovascular Surgery, Affiliated Shanghai 1st People's Hospital, Shanghai Jiaotong University, Shanghai 210008, People's Republic of China.
Journal of Cardiology
|May 21, 2013
Summary
Familial hypercholesterolemia (FH) is an inherited lipid metabolism disorder. This study identified gene networks and metabolic differences in FH patients, aiding biomarker discovery.
Area of Science:
- Genetics
- Metabolomics
- Systems Biology
Background:
- Familial hypercholesterolemia (FH) is an inherited disorder of lipid metabolism.
- It is characterized by elevated low-density lipoprotein cholesterol and premature coronary artery disease.
Purpose of the Study:
- To identify co-expressed gene pairs involved in FH progression using a systems biology approach.
- To construct a conserved co-expression network for FH.
- To explore differences in lipoprotein and cholesterol metabolism in FH patients.
Main Methods:
- Systems biology approach to identify co-expressed gene pairs.
- Construction of a conserved gene co-expression network.
- Analysis of lipoprotein and cholesterol metabolism in circulating immune cells (monocytes and lymphocytes) of FH patients versus controls.
Main Results:
- Identified 4232 significant co-expressed gene relationships, verified by random permutation.
- Observed distinct lipoprotein and cholesterol metabolism patterns in monocytes and lymphocytes of FH patients compared to healthy individuals.
Conclusions:
- The study provides insights into the molecular mechanisms underlying FH progression.
- The identified gene networks and metabolic differences may serve as a basis for FH biomarker identification.
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