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Replacement of Neisseria meningitidis C cc11/ET-15 variant by a cc103 hypervirulent clone, Brazil 2005-2011

Guilherme Sardinha1, Soraia Cordeiro, Erica Gomes

  • 1Instituto Nacional de Controle de Qualidade em Saude - FIOCRUZ, Rio de Janeiro, Brasil.

Diagnostic Microbiology and Infectious Disease
|May 21, 2013
PubMed

Insights

Serogroup C meningococcal outbreaks in Brazil were linked to a specific clone (cc11 variant ET-15). This clone has since been replaced by cc103, which requires monitoring to prevent further spread.

Area of Science:

  • Microbiology
  • Epidemiology
  • Public Health

Background:

  • Neisseria meningitidis serogroup C (MenC) outbreaks have been documented in Northeast Brazil.
  • The genetic landscape of MenC strains can evolve, impacting disease epidemiology.

Purpose of the Study:

  • To investigate the clonal evolution of serogroup C meningococci during outbreaks in Northeast Brazil.
  • To identify the dominant clones responsible for MenC infections and track their temporal replacement.

Main Methods:

  • Molecular typing of Neisseria meningitidis isolates.
  • Analysis of clonal complex (cc) distribution over time.
  • Surveillance data from Northeast Brazil (2005-2011).

Main Results:

  • Outbreaks from 2005-2011 were initially associated with a variant ET-15 of clonal complex 11 (cc11).
  • A shift in dominance occurred, with cc103 replacing cc11 variant ET-15 from 2006 onwards.
  • cc103 became the predominant clone in the region.

Conclusions:

  • The emergence and replacement of meningococcal clones (cc11 ET-15 by cc103) is a dynamic process.
  • Close monitoring of the increasing cc103 clone is crucial to prevent its dissemination to adjacent areas.
Keywords:
BrazilHypervirulent cloneMLSTMeningococcal diseaseNeisseria meningitidis C

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