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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events, are a...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: May 11, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

Altered brain structural connectivity in post-traumatic stress disorder: a diffusion tensor imaging tractography

Zhiliang Long1, Xujun Duan, Bing Xie

  • 1Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, PR China.

Journal of Affective Disorders
|May 21, 2013
PubMed
Summary

Post-traumatic stress disorder (PTSD) alters whole-brain network organization. Patients with PTSD show disrupted structural connectivity networks, impacting brain regions crucial for salience and memory.

Keywords:
Diffusion tensor tractographyPost-traumatic stress disorderSmall-worldnessStructural connectivity network

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Last Updated: May 11, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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Published on: July 1, 2014

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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Area of Science:

  • Neuroscience
  • Brain Imaging
  • Network Science

Background:

  • Post-traumatic stress disorder (PTSD) involves known dysfunctions in specific brain regions like the medial prefrontal gyrus and amygdala.
  • However, the impact of PTSD on the large-scale topological organization of structural brain networks is not well understood.

Purpose of the Study:

  • To investigate alterations in the topological organization of structural connectivity networks (SCNs) in patients with PTSD.
  • To explore how PTSD affects the global and nodal properties of brain networks.

Main Methods:

  • Utilized diffusion tensor tractography to construct SCNs in 17 motor vehicle accident survivors with PTSD and 15 healthy controls.
  • Applied graph theory analysis to examine topological properties of the SCNs based on 90 brain regions.

Main Results:

  • Patients with PTSD exhibited significantly decreased characteristic shortest path length and normalized characteristic shortest path length in their SCNs.
  • Enhanced nodal centralities were observed in the salience network (anterior cingulate, pallidum) and hippocampus/parahippocampus gyrus in PTSD patients.
  • Decreased nodal centralities were found in the medial orbital superior frontal gyrus of patients with PTSD.

Conclusions:

  • Findings suggest PTSD is associated with widespread dysfunction in large-scale neural networks, not just discrete regions.
  • The study provides structural evidence supporting network-based neurocircuitry models for PTSD.
  • This exploratory analysis highlights the need for further research with larger samples.