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[Polybrene thrombin time--a simple new method for monitoring a fibrinolytic therapy]
G Lutze1, T Schraermeyer, G Töpfer
1Institut für Klinische Chemie und Laboratoriumsdiagnostik, Medinischen Akademie Magdeburg.
The thrombin time is essential to control the fibrinolytic therapy with streptokinase. But it is not efficient to use the thrombin time to estimate the fibrinolytic activity if heparin is applied simultaneously. After addition of heparin antidote polybrene the results are comparable with the reptilase time (so-called polybrene thrombin time). In the case of a fibrinolytic therapy it is recommended to use the thrombin time according to AB-D.L. (heparin-sensitive method) and the polybrene thrombin time (heparin-insensitive method).
The thrombin time is essential to control the fibrinolytic therapy with streptokinase. But it is not efficient to use the thrombin time to estimate the fibrinolytic activity if heparin is applied simultaneously. After addition of heparin antidote polybrene the results are comparable with the reptilase time (so-called polybrene thrombin time). In the case of a fibrinolytic therapy it is recommended to use the thrombin time according to AB-D.L. (heparin-sensitive method) and the polybrene thrombin time (heparin-insensitive method).