Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

Brain Abscess l: Introduction

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...

Local Anesthetics: Clinical Application as Spinal Anesthesia

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

An automated decision making framework for modern vehicles CO<sub>2</sub> emissions using multi modal engine telemetry and feature interpretability.

Scientific reports·2026

Same author

Big multiple sclerosis data network: novel modelling approaches for real-world data analysis.

Journal of neurology·2025

Same author

Advancing computational evaluation of adsorption via porous materials by artificial intelligence and computational fluid dynamics.

Scientific reports·2025

Same author

Comparative effectiveness and cost-effectiveness of natalizumab and fingolimod in rapidly evolving severe relapsing-remitting multiple sclerosis in the United Kingdom.

Journal of medical economics·2023

Same author

Consensus guidelines on management of oral potentially malignant disorders.

Indian journal of cancer·2022

Same author

Comparison of the Length of Styloid Process in Panoramic Radiographs to Computed Tomography as the Gold Standard.

Journal of pharmacy & bioallied sciences·2022

Search research articles

Related Experiment Video

Updated: May 11, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

Aspergillus arachnoiditis post intrathecal baclofen pump insertion.

V Vivek¹, B Kavar, M Hogg

¹Department of General Medicine, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia. vinovivek19@gmail.com

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|May 21, 2013

Summary

This summary is machine-generated.

A rare fungal infection of an intrathecal baclofen pump occurred in a multiple sclerosis patient. Aspergillus terreus caused neurological decline, highlighting a previously unreported complication.

Keywords:

Aspergillus Baclofen Infection Intrathecal

Related Experiment Videos

Last Updated: May 11, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

Area of Science:

Neurology
Infectious Diseases
Medical Devices

Background:

Intrathecal baclofen pumps manage severe spasticity in conditions like multiple sclerosis.
Secondary progressive multiple sclerosis (SPMS) presents significant management challenges.

Observation:

A 39-year-old man with SPMS experienced neurological decline.
The decline was linked to an infection of his intrathecal baclofen pump.

Findings:

The infection was caused by Aspergillus terreus, a fungus.
This represents a previously unreported fungal infection complication of intrathecal baclofen pumps.

Implications:

Highlights the risk of rare fungal infections with implanted medical devices.
Emphasizes the need for vigilance in diagnosing neurological decline in patients with intrathecal pumps.
Suggests considering fungal etiologies in pump-related complications.