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Related Concept Videos

The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

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Related Experiment Video

Updated: May 11, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Periodontitis and stroke.

Michal Straka1, Michaela Trapezanlidis

  • 1Department of Stomatology, Slovak Health University, Bratislava, Slovakia. mudrstraka@r3.roburnet.sk

Neuro Endocrinology Letters
|May 21, 2013
PubMed
Summary

Chronic periodontitis, an oral inflammatory disease, is linked to stroke development. Oral infections can promote atherosclerosis, increasing stroke risk and impacting treatment strategies for post-stroke patients.

Area of Science:

  • Periodontology
  • Neurology
  • Immunology

Background:

  • Periodontitis is a destructive inflammatory oral disease influenced by genetic, immunological, and psychosocial factors.
  • Oral inflammation can lead to systemic dissemination of bacteria and inflammatory mediators.
  • Atherosclerosis, a major cause of ischemic stroke, involves metabolic, infectious, and immunological processes.

Purpose of the Study:

  • To review the epidemiological and etiopathogenetic links between chronic periodontitis and stroke.
  • To elucidate the relationship between oral infections and pro-atherogenetic mechanisms.
  • To discuss the principles of managing patients following a stroke.

Main Methods:

  • Literature review focusing on chronic periodontitis and stroke.

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Last Updated: May 11, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model
06:14

Induction of Periodontitis via a Combination of Ligature and Lipopolysaccharide Injection in a Rat Model

Published on: February 17, 2023

  • Analysis of etiological and pathogenetic mechanisms connecting oral health and cerebrovascular events.
  • Examination of treatment principles for post-stroke care.

    • Main Results:

    • Chronic periodontitis is associated with an increased risk of stroke.
    • Oral infections can stimulate pro-atherogenetic pathways, contributing to vascular disease.
    • Systemic inflammation originating from the oral cavity plays a role in atherosclerosis.

    Conclusions:

    • A significant association exists between chronic periodontitis and stroke.
    • Managing oral health is crucial for mitigating stroke risk.
    • Further research into the interplay between oral infections and cerebrovascular disease is warranted.