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Updated: May 11, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Cardiac resynchronization therapy in becker muscular dystrophy.

George Andrikopoulos¹, Spiros Kourouklis, Chrysanthi Trika

¹Department of Cardiology, Henry Dunant Hospital of Athens, Greece. andrikop@hotmail.com

Hellenic Journal of Cardiology : HJC = Hellenike Kardiologike Epitheorese

|May 21, 2013

Summary

Becker muscular dystrophy patients with heart failure can benefit from biventricular cardioverter-defibrillators (CRT-D). This cardiac resynchronization therapy improved a patient's heart function and symptoms within one month.

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Area of Science:

Cardiology
Medical Devices

Background:

Becker muscular dystrophy (BMD) can lead to non-ischemic dilated cardiomyopathy.
Patients may experience worsening heart failure (HF) and presyncope.
Left bundle branch block (LBBB) and mechanical dyssynchrony are common in these patients.

Observation:

A 44-year-old male with BMD and non-ischemic dilated cardiomyopathy presented with worsening heart failure (NYHA class III) and presyncope.
Echocardiography revealed left ventricular (LV) dilatation, hypertrabeculation, severely depressed systolic function (EF 20%), and significant mechanical dyssynchrony.

Findings:

A biventricular cardioverter-defibrillator (CRT-D) was implanted with leads positioned for optimal cardiac resynchronization.
Echocardiography-guided programming of the CRT-D device was performed to enhance atrio-, inter-, and intraventricular synchrony.

Implications:

CRT-D implantation led to substantial clinical improvement in the patient within one month post-implantation.
This case demonstrates the efficacy of CRT-D therapy in managing advanced heart failure secondary to Becker muscular dystrophy.